Background:
@EN While previous studies have suggested that glomerular hyperfiltration predicts future development of diabetic nephropathy in insulin-dependent-diabetes mellitus, its role in non-insulin-dependent diabetes mellitus is not defined.
@ES Method :
@EN We performed a follow-up study of the renal function in a series of 34 patients with NIDDM without clinical proteinuria, who had studied 13 month previously. GFR was determined by 51Gr-EDTA single injection method.
@ES Results:
@EN Glmerular hyperfiltration persisted in about two thirds of patients for at least 13 months. The GRF in hyperfiltration group decreased, but the GRF did not change in normofiltration group at follow-up. The rate of decline of GRF in
hyperfiltration
group (2.0±3.4ml/min/month) was greater than in normofiltration group (0.5±1.0ml/min/month)(p<0.05). At follow-up, 6 of 19 nomofiltrating and 2 of 15 hyperfiltrating patients progressed to incipient of overt nephropathy.
@ES Conclusion :
@EN Our study revealed that a high proportion of NIDDM patients have persistent glomerulr hyperfiltration. The rate of decline of GRF in hyperfiltration group was faster than that in normofiltration group. which was positively correlated with
initial
GRF. However, glomerular hyperfiltration per se, over a 13 months interval, did not predict the subsequent development f either incipient or overt diabetic nephropathy.
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